These are usually mild in severityĪnd will resolve within 12 hours of the ingestion. The initial signs and symptoms of acetaminophen toxicityĪre gastrointestinal, specifically nausea and vomiting.
The toxic dose of acetaminophen for an adult isġ0 grams or 200 mg/kg, whichever is less.Ģ0 grams or 300 mg/kg, whichever is less. NAPQI covalently binds to mitochondrial proteins in the hepatocytes,Ĭausing oxidative stress that impairs mitochondrial function and causes hepatic cell deathīy an overdose of acetaminophen, but liver damage is the most common effect. Reduced to approximately 20% to 30% of the pre-exposure levels, liver damage occurs. The liver are quickly diminished, and when the available amount of glutathione has been Saturated and a larger proportion of the drug is metabolized to NAPQI.
When a toxic amount ofĪcetaminophen is ingested, the glucuronide and sulfate pathways of metabolism become Much NAPQI is formed and how much glutathione is available. Acetaminophen toxicity represents an imbalance between how
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